Human Anaphase-promoting complex subunit 1 (ANAPC1) ELISA Kit

Este producto es parte de ANAPC - Anaphase-promoting complex subunit
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715€ (96 tests)

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935106861
info@markelab.com
name
Human Anaphase-promoting complex subunit 1 (ANAPC1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx502100
tested applications
ELISA

Description

Human Anaphase-promoting complex subunit 1 (ANAPC1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Anaphase-promoting complex subunit 1 (ANAPC1) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Anaphase-promoting complex subunit 1 (ANAPC1)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Availability
Shipped within 5-15 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q9H1A4
Alias
ANAPC1,TSG24,APC1
Background
Elisa Kits for: ANAPC1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Descripción

ANAPC1 is a core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), a large E3 ubiquitin ligase complex that regulates the progression of the cell cycle. ANAPC1 serves as a structural scaffold that supports the assembly and stability of the APC/C complex. The APC/C targets key cell cycle regulators such as cyclin B and securin for ubiquitin-mediated proteasomal degradation, ensuring the timely transition from metaphase to anaphase and promoting exit from mitosis. ANAPC1 is essential for maintaining chromosomal stability and proper segregation of sister chromatids during mitosis. Mutations or dysregulation of ANAPC1 have been linked to genomic instability, aneuploidy, and the development of cancers. Studies also suggest that defects in ANAPC1 can contribute to neurodevelopmental disorders and tissue-specific growth abnormalities due to impaired cell cycle regulation. Its central role in cell division highlights ANAPC1 as a potential therapeutic target for cancer and proliferative diseases.

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