Human Bcl-2 / Adenovirus E1B 19 kDa-Interacting Protein 2-Like Protein (BNIPL) Protein
1235€ (100 µg)
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name
Human Bcl-2 / Adenovirus E1B 19 kDa-Interacting Protein 2-Like Protein (BNIPL) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694049
tested applications
SDS-PAGE
Description
Bcl-2 / Adenovirus E1B 19 kDa-Interacting Protein 2-Like Protein (BNIPL) protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Bcl-2 / Adenovirus E1B 19 kDa-Interacting Protein 2-Like Protein (BNIPL) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ser2-Lys187 |
| Origin | Human |
| Observed MW | 20.4 kDa |
| Expression | Recombinant |
| Purity | > 88% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile 50 mM Tris, 150 mM NaCl, 1 mM DTT, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q7Z465-1 |
| Alias | BNIP3L,BNIP3A,BNIP3H,NIX,Adenovirus E1B19K-binding protein B5,BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like |
| Background | Protein BNIP3L |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
BCL2 Interacting Protein 3 Like (BNIP3L), also known as NIX, is a member of the BCL2 family of proteins and plays a critical role in programmed cell death and mitochondrial quality control. BNIP3L is known to interact with BCL2 and other apoptotic regulators, promoting mitochondrial autophagy (mitophagy), a selective process that removes damaged or dysfunctional mitochondria to maintain cellular homeostasis. Its function is particularly crucial under conditions of hypoxia, where BNIP3L is upregulated, contributing to cell survival by mitigating oxidative stress and preventing the accumulation of damaged mitochondria. In the context of erythroid maturation, BNIP3L is essential for mitophagy-mediated clearance of mitochondria, a necessary step in the development of red blood cells. Dysregulation of BNIP3L has been implicated in various pathologies, including cancer, where its role can vary between promoting cell death in some contexts and contributing to tumor survival and resistance in others. Additionally, alterations in BNIP3L function are associated with neurodegenerative diseases due to impaired mitochondrial dynamics and clearance. This duality highlights the importance of BNIP3L as a potential therapeutic target for addressing diseases linked to apoptosis and mitochondrial dysfunction.
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