Human C-Type Lectin Domain Family 4 Member A (CLEC4A) Protein

Este producto es parte de CLEC4A - C-type lectin domain family 4 member A
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975€ (50 µg)

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935106861
info@markelab.com
name
Human C-Type Lectin Domain Family 4 Member A (CLEC4A) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693207
tested applications
SDS-PAGE

Description

Human CLEC4A Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human CLEC4A (NP_057268.1) extracellular domain (Gln 70-Leu 237) was expressed, with a polyhistidine tag at the N-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
CLEC4A
Host
HEK293 cells
Assay Type
Activity: Not tested
Sequence Fragment: Gln70-Leu237
Tag: N-terminal His tag
Origin
Human
Observed MW
22 kDa
Expression
Recombinant
Purity
> 95% (SDS-PAGE)
Size 1
50 µg
Form
Lyophilized
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.
Dry Ice
No
NCBI Accession
NP_001128530.1
Alias
DCIR,LLIR,CD367,DDB27,hDCIR,CLECSF6,HDCGC13P,C-type lectin DDB27,C-type lectin superfamily member 6,Dendritic cell immunoreceptor,Lectin-like immunoreceptor
Background
Protein CLEC4A
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Endotoxin Level: < 1.0 EU per µg (LAL method).

Descripción

CLEC4A (C-type lectin domain family 4 member A), also known as DCIR (dendritic cell immunoreceptor), is a receptor found on the surface of various immune cells, particularly dendritic cells (DCs) and monocytes. CLEC4A is part of the C-type lectin receptor (CLR) family, a group of proteins that play key roles in the immune system, especially in pathogen recognition, immune homeostasis, and inflammatory responses. As a member of this family, CLEC4A can recognize and bind to carbohydrate structures found on pathogens, self-antigens, and damaged cells. This binding facilitates immune responses and communication between cells of the immune system. CLEC4A has an important immunomodulatory role and is involved in both activating and inhibitory signaling pathways. Its ability to bind self-antigens and regulate immune responses is critical in maintaining immune tolerance, thus preventing autoimmune responses. Its expression in dendritic cells and other antigen-presenting cells highlights its relevance in adaptive immunity, where it influences T-cell activation and the shaping of immune responses. Additionally, CLEC4A is implicated in various autoimmune diseases and infections, making it an important target for therapeutic research.
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