Human CD180 Antigen (CD180) Protein (Active)
975€ (50 µg)
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935106861
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name
Human CD180 Antigen (CD180) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx691822
tested applications
SDS-PAGE
Description
Human CD180 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human CD180 (NP_005573.2) extracellular domain (Met 1-Gly 626) was fused with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD180 |
| Host | HEK293 cells |
| Assay Type | Activity: Active Sequence Fragment: Met1-Gly626 Tag: C-terminal His tag |
| Origin | Human |
| Observed MW | 69 kDa |
| Expression | Recombinant |
| Purity | > 92% (SDS-PAGE) |
| Size 1 | 50 µg |
| Size 2 | 500 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_005573.2 |
| Alias | LY64,Ly78,RP105,Lymphocyte antigen 64,Radioprotective 105 kDa protein |
| Background | Protein CD180 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg as determined by the LAL method. |
Descripción
CD180, also known as RP105 (radioprotective 105 kDa protein), is a cell surface molecule prominently expressed on immune cells, particularly B cells, macrophages, and dendritic cells. As a member of the Toll-like receptor (TLR) family, CD180 plays a significant role in the immune system by recognizing microbial components and activating immune responses. Although structurally similar to TLRs, CD180 functions distinctly by forming complexes with other receptors rather than directly recognizing pathogen-associated molecular patterns (PAMPs). Its primary function is to regulate B cell activation, proliferation, and differentiation, which is crucial for antibody production and adaptive immunity. CD180 is a regulatory receptor that modulates the response of B cells to various antigens, providing an essential checkpoint in immune activation to avoid excessive immune responses and maintain balance.
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