Human Cell Adhesion Molecule 3 (CADM3) Protein
234€ (10 µg)
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name
Human Cell Adhesion Molecule 3 (CADM3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx690039
tested applications
SDS-PAGE
Description
Cell Adhesion Molecule 3 (CADM3) protein is a recombinant protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Cell Adhesion Molecule 3 (CADM3) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Asn25-His330 Tag: C-terminal 6 His tag |
| Origin | Human |
| Observed MW | Calculated MW: 34.7 kDa Observed MW (SDS-PAGE): 35-42 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | 0.2 µm filtered prior to lyophilization. |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM PBS, 150 mM NaCl, pH 7.2, containing 5%-8% Trehalose, Mannitol and 0.01% Tween 80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| Alias | BIgR,NECL1,TSLL1,CMT2FF,IGSF4B,Necl-1,synCAM3,TSLC1-like protein 1,Nectin-like protein 1,Immunoglobulin superfamily member 4B,Brain immunoglobulin receptor |
| Background | Protein CADM3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile H2O to prepare a stock solution of concentration 0.25 mg/ml. Do not vortex. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
CADM3, also known as SynCAM3 or nectin-like molecule 1 (Necl-1), is a neural cell adhesion molecule critical for axon-dendrite interactions, synaptic formation, and neural development. It is highly expressed in the nervous system, particularly in the brain, where it mediates the formation and maintenance of synaptic connections. CADM3 plays a crucial role in axon guidance and fasciculation, processes that are essential for proper neural circuit assembly during development. It facilitates both homophilic and heterophilic interactions with other adhesion molecules, contributing to the establishment of synaptic specificity and organization. CADM3 interacts with intracellular scaffolding proteins and signaling pathways to regulate actin cytoskeletal dynamics and intracellular signaling. Mutations or altered expression of CADM3 have been associated with neurodevelopmental disorders and cognitive deficits, highlighting its importance in brain function. Structurally, CADM3 contains extracellular Ig-like domains responsible for its adhesive properties and intracellular domains that anchor to the cytoskeleton and signaling complexes. CADM3's functions extend beyond the nervous system, as it is also expressed in epithelial tissues, where it contributes to cellular polarity and adhesion. Its role in tumor suppression has been explored, with evidence suggesting that CADM3 downregulation enhances tumor cell invasiveness and metastasis.
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