Human CXADR-Like Membrane Protein (CLMP) Protein
234€ (10 µg)
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name
Human CXADR-Like Membrane Protein (CLMP) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650838
tested applications
WB, SDS-PAGE
Description
Human CLMP Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CXADR-Like Membrane Protein (CLMP) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Thr19-Ser183 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 22.5 kDa Observed MW (SDS-PAGE): 23 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H6B4 |
| Gene ID | 79827 |
| NCBI Accession | NP_079045.1 |
| OMIM | 611693 |
| Alias | ACAM,ASAM,CSBM,CSBS,Adipocyte adhesion molecule,Coxsackie- and adenovirus receptor-like membrane protein,CAR-like membrane protein |
| Background | Protein CLMP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
CLMP is a transmembrane protein belonging to the immunoglobulin superfamily and shares structural similarity with the coxsackie and adenovirus receptor (CXADR). CLMP is widely expressed in epithelial and endothelial tissues, where it contributes to tight junction formation and maintenance of cell polarity. It mediates homophilic adhesion and strengthens intercellular junctions, playing a role in epithelial barrier integrity. Mutations in CLMP have been linked to congenital short bowel syndrome, a rare developmental disorder characterized by reduced intestinal length due to impaired embryonic gut elongation. CLMP is thought to regulate cellular signaling pathways that influence proliferation and differentiation during organogenesis. In addition to its developmental roles, CLMP has been implicated in regulating vascular permeability and may contribute to immune cell trafficking in inflammatory conditions. Structurally, CLMP contains extracellular immunoglobulin-like domains that mediate adhesion and intracellular domains that interact with cytoskeletal proteins to stabilize cell-cell junctions. Dysregulation of CLMP expression has been observed in certain cancers, suggesting a potential role in tumor progression and metastasis. Current research focuses on understanding its signaling mechanisms and exploring its therapeutic potential in tissue repair and developmental disorders.
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