Human Dedicator Of Cytokinesis 2 (DOCK2) Protein

221€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Dedicator Of Cytokinesis 2 (DOCK2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166509
tested applications
WB, SDS-PAGE
Description
Human Dedicator Of Cytokinesis 2 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Dedicator Of Cytokinesis 2 (DOCK2) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ile390-Glu635 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 31.7 kDa Observed MW (SDS-PAGE): 32 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92608 |
| Alias | DOCK2, IMD40, Dock2, dedicator of cytokinesis 2 |
| Background | Protein DOCK2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
DOCK2 is a hematopoietic-specific GEF expressed in leukocytes, activating Rac1/Rac2 to control chemotaxis and immune cell migration. It regulates lymphocyte development, T cell activation, and neutrophil responses to chemokines like CXCL12. DOCK2 interacts with ELMO1 to mediate actin polymerization, essential for leukocyte motility and immune responses. Dysregulation causes defects in lymphocyte trafficking and inflammation. In infections and cancer, DOCK2 can promote or suppress disease progression. Its activity depends on membrane lipids like PIP3 and phosphorylation. Knockout models show immunodeficiency and impaired immune surveillance, emphasizing DOCK2’s role in immunity.
Related Products

Dedicator of Cytokinesis 2 (DOCK2) Antibody
Dedicator Of Cytokinesis 2 Antibody is a Rabbit Polyclonal antibody against Dedicator Of Cytokinesis 2.
Ver Producto
Dedicator of Cytokinesis 2 (DOCK2) Antibody
DOCK2 Antibody is a Rabbit Polyclonal against DOCK2.
Ver Producto
Dedicator of Cytokinesis 2 (DOCK2) Antibody
Dedicator Of Cytokinesis 2 Antibody is a Rabbit Polyclonal against Dedicator Of Cytokinesis 2.
Ver Producto