Human Dedicator Of Cytokinesis Protein 6 (DOCK6) ELISA Kit

Este producto es parte de DOCK - Dedicator of Cytokinesis
Human Dedicator Of Cytokinesis Protein 6 (DOCK6) ELISA Kit
715€ (96 tests)

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Name
Human Dedicator Of Cytokinesis Protein 6 (DOCK6) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx386963
Tested Applications
ELISA

Description

Human Dedicator Of Cytokinesis Protein 6 (DOCK6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DOCK6 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
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Data sheet
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Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Dedicator Of Cytokinesis Protein 6 (DOCK6)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.312 ng/ml - 20 ng/ml
Sensitivity
< 0.1 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q96HP0
Gene ID
57572
OMIM
614194
Alias
DOCK6, KIAA1395,AOS2, ZIR1
Background
Elisa Kits for: DOCK6
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

DOCK6 is a dual GEF for Rac1 and Cdc42, critical for cytoskeleton regulation, neurite outgrowth, and axonal growth. It facilitates actin and microtubule dynamics, influencing processes like neuronal development and fibroblast migration. DOCK6 mutations are associated with Adams-Oliver syndrome, characterized by limb and scalp defects due to impaired cell migration. It is expressed in neural and connective tissues, where it regulates cellular polarity and adhesion. DOCK6 interacts with Rac1 to drive membrane protrusion and lamellipodia formation. Knockdown studies show defects in axonal elongation and cellular migration, underscoring its role in tissue development and repair.

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