Human High Mobility Group Protein B1 (HMGB1) Protein
234€ (5 µg)
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935106861
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name
Human High Mobility Group Protein B1 (HMGB1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx261998
tested applications
SDS-PAGE
Description
High Mobility Group Protein B1 (HMGB1) protein is a recombinant protein expressed in Hi-5 insect cells. It is a single, glycosylated polypeptide chain consisting of 223 amino acids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | High Mobility Group Protein B1 (HMGB1) |
| Host | Insect |
| Assay Type | Activity: Not tested Sequence Fragment: 1-215 AA. Tag: C-terminal 8 His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | 25 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Purification | Purified by proprietary chromatography techniques. <br> Sterile filtered. |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM Tris-HCl, pH 8, containing 1 mM EDTA, 0.5 mM DTT and 10% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4°C for up to 4 weeks. Store at -20 °C for long term storage. It is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09429 |
| Alias | HMG1,HMG3,HMG-1,SBP-1,Amphoterin |
| Background | Protein HMGB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Concentration: 1 mg/ml |
Descripción
HMGB1 is a non-histone nuclear protein involved in DNA repair, replication, and transcriptional regulation, but it also functions as a damage-associated molecular pattern (DAMP) protein when released extracellularly Upon cellular stress or necrosis, HMGB1 is actively secreted or passively released, triggering immune responses by interacting with receptors such as RAGE and TLR4 HMGB1 is critical in mediating inflammation, immune activation, and tissue injury, playing roles in diseases like sepsis, autoimmune disorders, and cancer It promotes cell migration, angiogenesis, and tumor progression, while dysregulated HMGB1 signaling is linked to chronic inflammation and metastasis Targeting HMGB1 holds therapeutic promise for modulating immune responses in inflammatory diseases, neurodegeneration, and cancer
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