Human Importin Subunit Alpha-2 (KPNA2) ELISA Kit
715€ (96 tests)
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Name
Human Importin Subunit Alpha-2 (KPNA2) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx152098
Tested Applications
ELISA
Description
Human Importin Subunit Alpha-2 (KPNA2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Karyopherin alpha 2 (KPNa2) concentrations in serum, plasma and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Karyopherin Alpha 2 (KPNa2)
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | Importin Subunit Alpha-2 (KPNA2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 125 pg/ml - 8000 pg/ml |
| Sensitivity | < 55 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | KPNA2,IPOA1, QIP2, RCH1, SRP1alpha, Karyopherin alpha 2, SRP1-alpha, karyopherin subunit alpha 2, PTAC58 |
| Background | Elisa Kits for: KPNA2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Background
KPNA2, also known as importin-α2, is a key nuclear transport adaptor protein that binds cargo proteins containing classical nuclear localization signals (NLS). It works in conjunction with importin-β to translocate the cargo through the nuclear pore complex (NPC) into the nucleus. KPNA2 is ubiquitously expressed and is involved in processes like gene expression, DNA repair, and cell proliferation. It has been shown to play a significant role in cancer biology, where overexpression of KPNA2 is associated with tumor progression, metastasis, and poor prognosis in cancers such as breast, lung, and liver cancers. KPNA2 also facilitates the nuclear import of viral proteins, making it a target in viral pathogenesis. Knockout studies indicate that KPNA2 is essential for cell viability and differentiation, particularly during embryogenesis and immune cell development.
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