Human Importin Subunit Alpha-5 (KPNA1) ELISA Kit
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Description
Human Importin Subunit Alpha-5 (KPNA1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human KPNA1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Importin Subunit Alpha-5 (KPNA1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P52294 |
| Gene ID | 3836 |
| OMIM | 600686 |
| Alias | KPNA1,IPOA5, NPI-1, RCH2, SRP1, Importin, Importin subunit alpha-5, karyopherin subunit alpha 1 |
| Background | Elisa Kits for: KPNA1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
KPNA1, also known as importin-α1, is a nuclear transport adaptor protein that mediates the import of cargo proteins containing classical nuclear localization signals (NLS) into the nucleus. It forms a heterodimer with importin-β, which facilitates the translocation of the cargo-importin complex through the nuclear pore complex (NPC) via energy-dependent mechanisms. KPNA1 is widely expressed and plays a critical role in nuclear-cytoplasmic transport during processes like transcription regulation, cell cycle progression, and stress responses. KPNA1 is involved in viral infection, where it mediates the nuclear import of viral proteins. Dysregulation of KPNA1 is linked to diseases such as cancer, where altered nuclear transport enhances oncogenic signaling. Knockout studies highlight its role in embryonic development, where impaired KPNA1 function leads to defects in gene regulation and cell growth.
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KPNA1 Antibody is a Rabbit Polyclonal antibody against KPNA1. The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].
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