Human Interferon Gamma Receptor 1 (IFNGR1) Protein
221€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Interferon Gamma Receptor 1 (IFNGR1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166500
tested applications
WB, SDS-PAGE
Description
Human Interferon Gamma Receptor 1 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interferon Gamma Receptor 1 (IFNGR1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Glu18-Gly245 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 29.5 kDa Observed MW (SDS-PAGE): 29 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15260 |
| Alias | IFN-gamma receptor 1,IFN-gamma-R1,CD119,IFNGR,IMD27A,IMD27B,CDw119,Interferon gamma receptor alpha-chain |
| Background | Protein IFNGR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in ddH2O to a concentration between 0.1-0.2 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 50 µg/ml |
Descripción
Interferon Gamma Receptor 1 (IFNGR1) is a pivotal transmembrane protein that serves as the primary receptor for interferon-gamma (IFN-γ), a crucial cytokine involved in innate and adaptive immune responses. IFNGR1 is predominantly expressed on the surface of immune cells, such as macrophages, T lymphocytes, and natural killer (NK) cells, and also on various non-immune cell types. Structurally, IFNGR1 is composed of an extracellular domain that binds IFN-γ, a transmembrane region, and a cytoplasmic tail that interacts with downstream signaling components. Upon IFN-γ binding, IFNGR1 forms a functional receptor complex with IFNGR2, initiating the JAK-STAT signaling cascade. This pathway leads to the activation of STAT1, which translocates to the nucleus to regulate the transcription of genes involved in antimicrobial defense, antigen presentation, and immune cell differentiation. Genetic mutations or deficiencies in IFNGR1 can result in immunodeficiencies, such as Mendelian susceptibility to mycobacterial diseases (MSMD), characterized by impaired responses to intracellular pathogens like mycobacteria and certain viruses. Due to its central role in immune regulation, IFNGR1 is extensively studied in the context of infectious diseases, autoimmunity, and cancer immunotherapy, where modulating its activity could enhance immune responses or mitigate pathological inflammation.
Related Products
Human IFNGR1 (Interferon gamma receptor 1) ELISA Kit
Ver Producto
IFNGR1 antibody
Associates with IFNGR2 to form a receptor for the cytokine interferon gamma(IFNG)(PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway(PubMed:7673114).
Ver Producto