Human Jagged 1 Protein (JAG1) Protein
208€ (10 µg)
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name
Human Jagged 1 Protein (JAG1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067572
tested applications
WB, SDS-PAGE
Description
Human Jagged 1 Protein (JAG1) is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Jagged 1 Protein (JAG1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Val836-Ser1047 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 24.3 kDa Observed MW (SDS-PAGE): 25 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P78504 |
| Alias | Protein jagged-1,AGS,AHD,AWS,HJ1,AGS1,DCHE,CD339,JAGL1,CMT2HH,Jagged1 |
| Background | Protein JAG1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Jagged-1 (JAG1) is a critical ligand within the Notch signaling pathway, a key cell-to-cell communication mechanism that regulates cellular differentiation, proliferation, and apoptosis. This pathway is pivotal during embryonic development and maintains tissue homeostasis in adults. JAG1, specifically, is one of the five canonical Notch ligands (alongside JAG2, DLL1, DLL3, and DLL4) and is highly involved in multiple developmental processes such as neurogenesis, vasculogenesis, and skeletal development. The interaction of JAG1 with Notch receptors triggers a series of proteolytic cleavages and releases the Notch intracellular domain (NICD), which translocates to the nucleus and activates target gene transcription. Dysregulation of JAG1 or aberrations in the Notch pathway are linked to congenital disorders, cancers, and other pathological conditions. In particular, mutations in JAG1 are associated with Alagille syndrome, a multisystem disorder affecting the liver, heart, and other organs.
