Human Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) Protein

247€ (10 µg)
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name
Human Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067649
tested applications
WB, SDS-PAGE
Description
Human Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: His22-Ala304 Tag: N-terminal His tag and GST tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 61.3 kDa Observed MW (SDS-PAGE): 60 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P43628 |
| Alias | CD158 antigen-like family member B2,KIR-023GB,Killer inhibitory receptor cl 2-3,NKAT2a,NKAT2b,GL183,CD158b,KIR2DL |
| Background | Protein KIR2DL3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Endotoxin Level: <1.0 EU per 1µg (determined by the LAL method) Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
KIR2DL3 is an inhibitory receptor that is part of the killer cell immunoglobulin-like receptor (KIR) family, which is primarily expressed on natural killer (NK) cells and some T-cell subsets. This receptor plays a pivotal role in immune surveillance and modulation by binding to specific HLA class I molecules, particularly HLA-C alleles, on potential target cells. KIR2DL3 recognizes HLA-C1 (characterized by an asparagine at position 80), which is different from HLA-C2 (lysine at position 80) recognized by related receptors like KIR2DL1. By binding to HLA-C1, KIR2DL3 sends inhibitory signals that regulate NK cell cytotoxicity, promoting immune tolerance and minimizing the risk of autoimmunity. The KIR genes, including KIR2DL3, are located on chromosome 19q13.4 in a highly polymorphic region known as the leukocyte receptor complex (LRC). Genetic variability within this complex, particularly in the KIR2DL3 and its HLA-C ligands, contributes to diversity in immune response among individuals. Variants in KIR2DL3 and other KIR genes are associated with differential susceptibility to diseases, including autoimmune disorders, viral infections, and cancers.
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