Human Leucine-Rich Repeat-Containing Protein 25 (LRRC25) Protein

Product specifications

Proteins and Peptides

Leucine-Rich Repeat-Containing Protein 25 (LRRC25)

HEK293 cells

Activity: Not tested
Sequence Fragment: Leu21-Thr165
Tag: C-terminal 6 His tag

Human

Calculated MW: 16.7 kDa  Observed MW (SDS-PAGE): 20-40 kDa

Recombinant

> 95% (SDS-PAGE)

0.2 µm filtered prior to lyophilization.

10 µg

50 µg

Lyophilized

SDS-PAGE

Prior to lyophilization: 20 mM PBS,150 mM NaCl,pH 7.4, containing 5%-8% Trehalose, Mannitol and 0.01% Tween 80.

Shipped within 5-15 working days.

Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.

No

Q8N386

126364

607518

LRRC25,MAPA,Monocyte and plasmacytoid-activated protein

Protein LRRC25

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Reconstitute in sterile H2O to prepare a stock solution of concentration 0.25 mg/ml. Do not vortex.
Endotoxin Level: < 1.0 EU per µg (LAL method).

Descripción

LRRC25 is an innate immune receptor predominantly expressed in neutrophils and macrophages where it plays a role in mediating the immune response against infections and cellular stress it functions as a regulator of toll-like receptor (TLR) and nuclear factor-kappa B (NF-κB) signaling pathways essential for pro-inflammatory cytokine production and pathogen clearance studies show that LRRC25 is involved in the recognition of damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) facilitating the recruitment of immune cells to sites of infection or injury it also participates in the regulation of neutrophil extracellular traps (NETs) which are critical in trapping and neutralizing pathogens dysregulated LRRC25 activity has been linked to chronic inflammatory diseases and autoimmune disorders ongoing research is investigating its potential role as a therapeutic target in modulating hyperactive inflammatory responses and its involvement in the crosstalk between innate and adaptive immunity

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