Human Leucine-Rich Repeat-Containing Protein 3B (LRRC3B) Protein

Este producto es parte de LRRC - Leucine-rich repeat-containing protein
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273€ (10 µg)

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935106861
info@markelab.com
name
Human Leucine-Rich Repeat-Containing Protein 3B (LRRC3B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx690652
tested applications
SDS-PAGE

Description

Leucine-Rich Repeat-Containing Protein 3B (LRRC3B) protein is a recombinant Human protein expressed in HEK293 cells.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Leucine-Rich Repeat-Containing Protein 3B (LRRC3B)
Host
HEK293 cells
Assay Type
Activity: Not tested
Sequence Fragment: Cys34-Tyr204
Tag: C-terminal 6 His tag
Origin
Human
Observed MW
Calculated MW: 20.0 kDa  Observed MW (SDS-PAGE): 52 kDa
Expression
Recombinant
Purity
> 95% (SDS-PAGE)
Purification
0.2 µm filtered prior to lyophilization.
Size 1
10 µg
Size 2
50 µg
Form
Lyophilized
Tested Applications
SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris-HCl, 150 mM NaCl, pH 8.0, containing 5%-8% Trehalose, Mannitol and 0.01% Tween 80.
Availability
Shipped within 5-15 working days.
Storage
Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.
Dry Ice
No
UniProt ID
Q96PB8
Gene ID
116135
OMIM
618996
Alias
LRRC3B, LRP15,Leucine-rich repeat protein 15
Background
Protein LRRC3B
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Reconstitute in sterile H2O to prepare a stock solution of concentration 0.25 mg/ml. Do not vortex.
Endotoxin Level: < 1.0 EU per µg (LAL method).

Descripción

LRRC3B is a tumor suppressor protein expressed in various tissues where it modulates cell growth and apoptosis its expression is frequently downregulated in cancers such as gastric colorectal and breast cancer due to epigenetic silencing through promoter hypermethylation LRRC3B is believed to inhibit cancer progression by modulating Wnt/β-catenin signaling and other pathways involved in cell proliferation and survival loss of LRRC3B function contributes to tumorigenesis by disrupting cell cycle regulation and enhancing cellular migration and invasion studies indicate it may also influence the tumor microenvironment by regulating extracellular matrix remodeling and cell-cell adhesion its potential as a biomarker for early cancer detection and prognosis is being actively explored as is its reactivation through epigenetic therapies targeting promoter methylation further research is necessary to fully characterize its tumor-suppressive mechanisms and therapeutic applications in oncology
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