Human Natriuretic Peptide Receptor 3 (NPR3) ELISA Kit
715€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Natriuretic Peptide Receptor 3 (NPR3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx152547
tested applications
ELISA
Description
Human Natriuretic Peptide Receptor 3 (NPR3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Natriuretic Peptide Receptor 3 (NPR3) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Natriuretic Peptide Receptor 3 (NPR3)
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Natriuretic Peptide Receptor 3 (NPR3) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | NPRC,ANP-C,ANPRC,BOMOS,NPR-C,ANPR-C,GUCY2B,C5orf23,Atrial natriuretic peptide receptor type C,Atrial natriuretic peptide clearance receptor |
| Background | Elisa Kits for: NPR3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
NPR3, also known as the natriuretic peptide clearance receptor, binds all three natriuretic peptides (ANP, BNP, and CNP) but does not have intrinsic guanylyl cyclase activity. Instead, NPR3 functions as a clearance receptor, removing natriuretic peptides from circulation and modulating their bioavailability and effects. NPR3 is expressed in various tissues, including the heart, kidney, and vascular system, where it regulates peptide levels to maintain cardiovascular and renal homeostasis. NPR3's role in limiting natriuretic peptide activity impacts blood pressure regulation, vascular remodeling, and fluid balance. Genetic polymorphisms in NPR3 have been linked to hypertension, heart failure, and obesity, highlighting its role in metabolic and cardiovascular health. In addition to clearance, NPR3 signaling influences cellular processes through its ability to couple with inhibitory G proteins, affecting cAMP levels and downstream pathways. NPR3-mediated clearance of CNP is critical for controlling vascular tone and endothelial function, underscoring its regulatory importance. Recent studies suggest that modulating NPR3 activity could enhance natriuretic peptide signaling, offering therapeutic potential for managing cardiovascular and metabolic disorders.
Related Products
NPR3 antibody
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
Ver Producto
Recombinant Human NPR3
Ver Producto
Natriuretic Peptide Receptor 3 (NPR3) Antibody
NPR3 Antibody is a Rabbit Polyclonal Antibody against NPR3.
Ver Producto