Human Natural Cytotoxicity Triggering Receptor 2 (NCR2) Protein

Product specifications

Proteins and Peptides

Natural Cytotoxicity Triggering Receptor 2 (NCR2)

HEK293 cells

Activity: Not tested
Sequence Fragment: Met1-Pro190
Tag: C-terminal His tag

Human

Calculated MW: 20 kDa  Observed MW (SDS-PAGE): 37 kDa

Recombinant

>88% (SDS-PAGE)

20 µg

100 µg

500 µg

1 mg

Lyophilized

SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80.

Shipped within 5-15 working days.

Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.

No

O95944

Lymphocyte antigen 95 homolog,LY95,CD336,NKP44,NK-p44,NK cell-activating receptor,Natural killer cell p44-related protein

Protein NCR2

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Reconstitute in sterile H2O. Do not vortex.
Endotoxin Level: < 1.0 EU per µg (LAL method).

Descripción

Natural Cytotoxicity Triggering Receptor 2 (NCR2), also known as NKp44, is an activating receptor on the surface of natural killer (NK) cells. NK cells are crucial components of the innate immune system, specializing in the recognition and destruction of abnormal cells, including tumor cells and virus-infected cells. Unlike other immune cells, such as T and B lymphocytes, which rely on antigen-specific receptors, NK cells use NCR2 and other activating receptors to identify stressed, infected, or transformed cells without prior sensitization. This unique ability enables NK cells to mount a rapid immune response. NCR2 is part of the NCR family, which also includes NCR1 (NKp46) and NCR3 (NKp30). These receptors, along with others like NKG2D, enable NK cells to recognize target cells that exhibit ligands associated with cellular stress or infection. NCR2 is specifically expressed on activated NK cells and is involved in both direct cytotoxicity and the secretion of cytokines and chemokines, amplifying the immune response. NCR2 plays an essential role in immune surveillance, contributing to the early detection and elimination of tumors and infection.

Related Products

Human NKp44/NCR2 (Natural cytotoxicity triggering receptor 2) ELISA Kit

Ver Producto

NCR2 antibody

Ver Producto

Recombinant Human NKp44

Ver Producto