Human Neutral Sphingomyelinase Activation Associated Factor (NSMAF) Protein

221€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Neutral Sphingomyelinase Activation Associated Factor (NSMAF) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166616
tested applications
WB, SDS-PAGE
Description
Human Neutral Sphingomyelinase Activation Associated Factor Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Neutral Sphingomyelinase Activation Associated Factor (NSMAF) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Arg176-Arg575 Tag: N-terminal His tag and GST tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 76.5 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | FAN,GRAMD5,Protein FAN |
| Background | Protein NSMAF |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Neutral sphingomyelinase activation associated factor (NSMAF) is a key protein involved in the regulation of sphingomyelin metabolism, specifically in the activation of neutral sphingomyelinase (nSMase). This enzyme plays an important role in generating ceramide, a lipid molecule involved in various cellular processes, including apoptosis, cell differentiation, and membrane integrity. NSMAF functions as an activator of nSMase, and its activity is crucial for the proper regulation of sphingomyelinase signaling pathways. The activation of nSMase by NSMAF is essential for maintaining cellular homeostasis and regulating lipid metabolism, especially in response to external stimuli such as oxidative stress or inflammatory signals. Disruption of NSMAF function can lead to abnormal ceramide production, which has been linked to several diseases, including neurodegenerative conditions, cancers, and metabolic disorders. Understanding the role of NSMAF in sphingomyelinase regulation is important for developing potential therapeutic strategies targeting ceramide-related pathways in various diseases.
Related Products

Protein FAN (NSMAF) Antibody
Protein FAN (NSMAF) antibody is a Rabbit polyclonal against Protein FAN (NSMAF).
Ver Producto
Neutral Sphingomyelinase Activation Associated Factor (NSMAF) Antibody
Neutral Sphingomyelinase Activation Associated Factor Antibody is a Rabbit Polyclonal against Neutral Sphingomyelinase Activation Associated Factor.
Ver Producto
Human Neutral Sphingomyelinase Activation Associated Factor (NSMAF) ELISA Kit
Human Neutral Sphingomyelinase Activation Associated Factor (NSMAF) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Neutral Sphingomyelinase Activation Associated Factor concentrations in tissue homogenates, cell lysates and other biological fluids.
Ver Producto