Human Parathyroid Hormone 2 Receptor (PTH2R) ELISA Kit

Este producto es parte de PTHR - Parathyroid Hormone Receptor
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643.5€ (96 tests)

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935106861
info@markelab.com
name
Human Parathyroid Hormone 2 Receptor (PTH2R) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx152888
tested applications
ELISA

Description

Human Parathyroid Hormone 2 Receptor (PTH2R) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Parathyroid Hormone 2 Receptor (PTH2R) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Parathyroid Hormone 2 Receptor (PTH2R)

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
ELISA Kits
Immunogen Target
Parathyroid Hormone 2 Receptor (PTH2R)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.312 ng/ml - 20 ng/ml
Sensitivity
< 0.12 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
P49190
Alias
PTH2R,PTHR2
Background
Elisa Kits for: PTH2R
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Descripción

PTH2R is a G protein-coupled receptor activated primarily by tuberoinfundibular peptide of 39 residues (TIP39) and, to a lesser extent, parathyroid hormone (PTH). Unlike PTH1R, PTH2R is not involved in calcium homeostasis but instead regulates neuroendocrine functions, pain signaling, and vasodilation. PTH2R is predominantly expressed in the central nervous system, including the hypothalamus and brainstem, as well as in pancreatic and cardiovascular tissues. It couples to Gs proteins, stimulating adenylate cyclase and increasing intracellular cAMP levels. PTH2R modulates neuropeptide release, pain perception, and stress responses. Emerging evidence suggests its involvement in regulating hypothalamic-pituitary functions and modulating blood flow. Dysregulation of PTH2R signaling is linked to altered pain sensitivity, stress-related disorders, and neuroendocrine dysfunction. Targeting PTH2R has therapeutic potential for managing chronic pain, stress disorders, and cardiovascular regulation, highlighting its role in neuropeptide-mediated signaling.

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