Human SH2 Domain Containing 1B (SH2D1B) Protein
234€ (2 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human SH2 Domain Containing 1B (SH2D1B) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx680108
Tested Applications
SDS-PAGE
Description
Human SH2 Domain Containing 1B (SH2D1B) Protein is a recombinant protein produced in Sf9, Baculovirus cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | SH2 Domain Containing 1B (SH2D1B) |
| Host | Insect |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | SH2D1B, EAT2 |
| Background | Protein SH2D1B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SH2D1B, also known as EAT-2 (EWS-FLI1-activated transcript 2), is an SH2 domain-containing adaptor protein that regulates signaling pathways downstream of SLAM family receptors, particularly in innate immune cells like NK cells, macrophages, and dendritic cells. It binds to SLAM receptors and modulates their signaling, influencing NK cell cytotoxicity, macrophage activation, and cytokine production. SH2D1B promotes immune responses by enhancing IFN-γ production, immune synapse formation, and innate immune cell activation. It functions as a positive regulator of SLAM signaling, in contrast to SH2D1A, which can have inhibitory roles depending on context. Dysregulation of SH2D1B is associated with impaired innate immune responses, susceptibility to infections, and inflammatory disorders. Knockout studies reveal reduced NK cell function, impaired macrophage activation, and defective cytokine responses, highlighting its role in fine-tuning innate immunity and SLAM receptor signaling.
Productos relacionados
SH2 Domain Containing 1B (SH2D1B) Antibody
Rabbit polyclonal antibody against SH2D1B protein. Immunogen region is Internal.…
Ver producto
Sh2 Domain Containing 1B (SH2D1B) Antibody
Sh2 Domain Containing 1B Antibody is a Rabbit Polyclonal antibody against Sh2 Domain Containing 1B.…
Ver producto
SH2 Domain Containing 1B (SH2D1B) Antibody
SH2D1B Antibody is a Rabbit Polyclonal against SH2D1B.…
Ver producto