Human Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Protein

Este producto es parte de SLAMF7 - SLAM family member 7
Human Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Protein
234€ (10 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

Name
Human Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx167045
Tested Applications
WB, SDS-PAGE

Description

Human SLAMF7 Protein is a recombinant Human protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Ser23-Met226
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Observed MW
Calculated MW: 26.5 kDa  Observed MW (SDS-PAGE): 28 kDa
Expression
Recombinant
Purity
> 80%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q9NQ25
Alias
CD2 subset 1,19A,CS1,CD319,CRACC,CD2-like receptor-activating cytotoxic cells,Membrane protein FOAP-12
Background
Protein SLAMF7
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Endotoxin Level: < 1.0 EU/µg (determined by the LAL method)
Concentration: Prior to lyophilization: 200 µg/ml

Background

SLAMF7 (SLAM Family Member 7), also known as CS1 (CD2 subset 1) or CRACC (CD319), is a cell surface glycoprotein belonging to the Signaling Lymphocyte Activation Molecule (SLAM) family within the immunoglobulin superfamily. SLAMF7 is primarily expressed on the surface of immune cells, especially on natural killer (NK) cells, plasma cells, and certain T-cell subsets, as well as dendritic cells and monocytes. This receptor plays a key role in immune cell activation, adhesion, and signal transduction, significantly influencing immune responses. SLAMF7 is particularly relevant in the context of immune surveillance and tumor cell recognition, as it acts as a co-stimulatory molecule for NK cells, enhancing their cytotoxic function against abnormal cells. In the tumor microenvironment, SLAMF7 can either promote anti-tumor immunity or, in some cases, contribute to immune evasion mechanisms that facilitate cancer cell survival. Its expression in multiple myeloma, where it is typically highly expressed, has made it a target for immunotherapy. The development of monoclonal antibodies against SLAMF7, like elotuzumab, has underscored its significance in cancer therapy.

Productos relacionados

abx004430

Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Antibody

SLAMF7 Antibody is a Rabbit Polyclonal antibody against SLAMF7.…

Ver producto
abx115587

Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Antibody

SLAMF7 Antibody is a Rabbit Polyclonal antibody against SLAMF7.…

Ver producto
abx122207

Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) Antibody

Rabbit Polyclonal against the SLAMF7 protein.…

Ver producto