Human TNF receptor-associated factor 1 (TRAF1) ELISA Kit
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Human TNF receptor-associated factor 1 (TRAF1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human TRAF1 concentrations in serum, plasma and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | TNF receptor-associated factor 1 (TRAF1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.188 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q13077 |
| Gene ID | 7185 |
| OMIM | 601711 |
| Alias | TRAF-1,TRAF1,EBI6, MGC:10353, TNF receptor associated factor 1 |
| Background | Elisa Kits for: TRAF1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
TRAF1 is an adaptor protein in the tumor necrosis factor receptor (TNFR) superfamily signaling pathways, playing a role in regulating NF-κB and MAPK activation, apoptosis, and immune responses. TRAF1 interacts with TNFR1, TNFR2, and other members of the TNF receptor family to mediate downstream signaling, promoting survival and inflammatory responses. TRAF1 is predominantly expressed in immune cells, including T cells, B cells, and macrophages, where it modulates cytokine production and apoptosis inhibition. It forms heterodimers with TRAF2 to regulate receptor complex formation and downstream signal transduction. Dysregulation of TRAF1 contributes to autoimmune diseases, chronic inflammation, and certain cancers by altering TNF signaling and immune responses. Knockdown studies show defects in cytokine production, reduced NF-κB activation, and increased susceptibility to apoptosis, underscoring its role in balancing immune homeostasis and cell survival pathways.
Related Products
TRAF1 antibody
Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
Ver ProductoTRAF1 antibody
Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
Ver Producto