Human TRAF Family Member Associated NFKB Activator (TANK) Protein

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Especificaciones del producto

Proteins and Peptides

TRAF Family Member Associated NFKB Activator (TANK)

E. coli

Activity: Not tested
Sequence Fragment: Leu131-Ile369
Tag: N-terminal His tag

Human

Unconjugated

Calculated MW: 30.3 kDa

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.

No

TANK,I-TRAF, ITRAF, TRAF2, TRAF family member associated NFKB activator

Protein TANK

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

TRAF family member-associated NF-kappa-B activator (TANK) is an adaptor protein involved in the regulation of NF-kappa-B signaling pathways, which play crucial roles in immune and inflammatory responses, cell survival, and apoptosis. TANK functions as a scaffold protein that interacts with members of the TRAF family, such as TRAF2, TRAF3, and TRAF6, to modulate the activation of kinases like IKK (I-kappa-B kinase), which are critical for NF-kappa-B activation. It acts as a negative regulator in certain contexts by inhibiting overactivation of signaling pathways, thereby preventing excessive inflammatory responses. TANK is also implicated in antiviral immunity, as it participates in the regulation of type I interferon production through interactions with signaling components like TBK1 and IKKε. Dysregulation of TANK expression or mutations can contribute to immune-related disorders, including autoimmune diseases and chronic inflammatory conditions, where abnormal NF-kappa-B activity is a hallmark. TANK's role extends to maintaining homeostasis in B-cell development and antibody production, further highlighting its importance in adaptive immunity. Additionally, post-translational modifications of TANK, such as ubiquitination and phosphorylation, influence its activity and interactions, ensuring precise control of signaling dynamics in response to cellular and extracellular stimuli.

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