Human Transmembrane Emp24 Domain-Containing Protein 1 (TMED1) Protein (Active)
1235€ (100 µg)
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935106861
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name
Human Transmembrane Emp24 Domain-Containing Protein 1 (TMED1) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692409
tested applications
SDS-PAGE
Description
Transmembrane Emp24 Domain-Containing Protein 1 (TMED1) protein is a recombinant Human protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Transmembrane Emp24 Domain-Containing Protein 1 (TMED1) |
| Host | HEK293 cells |
| Assay Type | Activity: Active Sequence Fragment: Met1-Asn194 Tag: C-terminal His tag |
| Origin | Human |
| Observed MW | 20.6 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q13445 |
| Gene ID | 11018 |
| OMIM | 605395 |
| Alias | TMED1,IL1RL1LG,IL1RL1L,Tp24; p24g1 |
| Background | Protein TMED1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
TMED1, a member of the p24 protein family, is a type I transmembrane protein involved in vesicular trafficking, particularly in the early secretory pathway. TMED1 localizes to the endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and the Golgi apparatus, where it regulates the transport and sorting of cargo proteins between cellular compartments. It interacts with coat protein complexes (COPI and COPII) to facilitate vesicle budding, cargo selection, and trafficking efficiency. TMED1 also plays a role in cellular signaling and homeostasis through its interaction with membrane-bound receptors and secretory proteins. It is widely expressed in various tissues, particularly in secretory cells and immune tissues, where it supports protein maturation, secretion, and immune regulation. Dysregulation of TMED1 has been linked to cancers and immune dysfunction, where altered trafficking pathways impair protein sorting and cellular communication. Knockdown studies show defects in vesicle formation, impaired protein transport, and disrupted Golgi integrity, emphasizing its role in maintaining secretory pathway dynamics, intracellular signaling, and cellular homeostasis.
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