Human Tumor Necrosis Factor Receptor Superfamily Member 8 / CD30 (TNFRSF8) Protein (Active)
780€ (100 µg)
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name
Human Tumor Necrosis Factor Receptor Superfamily Member 8 / CD30 (TNFRSF8) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx691653
tested applications
SDS-PAGE
Description
Human CD30 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human TNFRSF8 (NP_001234.2) extracellular domain (Met 1-Lys 379) was expressed, fused with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD30 |
| Host | HEK293 cells |
| Assay Type | Activity: Active Sequence Fragment: Met1-Lys379 Tag: C-terminal His tag |
| Origin | Human |
| Observed MW | 40 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_001234.2 |
| Alias | CD30,Ki-1,D1S166E,CD30L receptor,Lymphocyte activation antigen CD30,Tumor necrosis factor receptor superfamily member 8 |
| Background | Protein TNFRSF8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg as determined by the LAL method. |
Descripción
TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily Member 8), also known as CD30, is a cell surface receptor belonging to the tumor necrosis factor receptor (TNFR) superfamily. This family is composed of receptors that play critical roles in modulating immune responses, inflammation, and apoptosis. CD30 is primarily expressed on activated T and B cells, and its expression is upregulated in certain immune-related diseases and cancers, particularly Hodgkin lymphoma and anaplastic large cell lymphoma (ALCL). It has emerged as a significant target in cancer immunotherapy and as a diagnostic marker for lymphoma. The receptor is a hallmark of classical Hodgkin lymphoma (cHL) and ALCL due to its overexpression on malignant cells. Beyond cancer, CD30 has implications in the regulation of immune homeostasis, playing a role in T-cell activation, differentiation, and proliferation. Dysregulation of CD30 signaling can lead to chronic inflammation and the development of autoimmune disorders, making it an essential molecule of interest in both oncology and immunology.
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