Importin Subunit Alpha-5 (KPNA1) Antibody
442€ (200 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Importin Subunit Alpha-5 (KPNA1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430365
tested applications
P-ELISA, WB
Description
KPNA1 Antibody is a Goat Polyclonal antibody against KPNA1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Importin Subunit Alpha-5 (KPNA1) Immunogen: abx269465 - N-Terminus: TTPGKENFRLKSY-C |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 3836, 16646, 288064 |
| NCBI Accession | NP_002255.3 |
| Alias | KPNA1,IPOA5, NPI-1, RCH2, SRP1, Importin, Importin subunit alpha-5, karyopherin subunit alpha 1 |
| Background | Antibody anti-KPNA1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
KPNA1, also known as importin-α1, is a nuclear transport adaptor protein that mediates the import of cargo proteins containing classical nuclear localization signals (NLS) into the nucleus. It forms a heterodimer with importin-β, which facilitates the translocation of the cargo-importin complex through the nuclear pore complex (NPC) via energy-dependent mechanisms. KPNA1 is widely expressed and plays a critical role in nuclear-cytoplasmic transport during processes like transcription regulation, cell cycle progression, and stress responses. KPNA1 is involved in viral infection, where it mediates the nuclear import of viral proteins. Dysregulation of KPNA1 is linked to diseases such as cancer, where altered nuclear transport enhances oncogenic signaling. Knockout studies highlight its role in embryonic development, where impaired KPNA1 function leads to defects in gene regulation and cell growth.
Related Products
Importin Subunit Alpha-5 (KPNA1) Peptide
Importin Subunit Alpha-5 (KPNA1) Peptide is a synthetic peptide. This peptide is used in the production of
Ver Producto