Importin Subunit Alpha-7 (KPNA6) Antibody
442€ (200 µl)
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935106861
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name
Importin Subunit Alpha-7 (KPNA6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431377
tested applications
P-ELISA, WB, IHC
Description
KPNA6 Antibody is a Goat Polyclonal antibody against KPNA6.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Importin Subunit Alpha-7 (KPNA6) Immunogen: abx615538 - internal: C-STTGESVITREMVE |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 23633, 16650, 362607 |
| NCBI Accession | NP_036448.1 |
| Alias | KPNA6,IPOA7,Importin subunit alpha-7 |
| Background | Antibody anti-KPNA6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
KPNA6, also called importin-α7, is a nuclear transport adaptor protein that interacts with importin-β to mediate the nuclear import of cargo proteins containing classical nuclear localization signals (NLS). It plays key roles in cellular processes such as transcriptional regulation, cell cycle control, and DNA repair. KPNA6 is highly expressed in embryonic tissues, germ cells, and immune cells, where it supports cellular differentiation and developmental processes. It has been implicated in nuclear import during viral infections, where it facilitates the entry of viral proteins into the nucleus. Dysregulation of KPNA6 is associated with developmental defects, cancer progression, and immune dysfunction. Knockout studies reveal its critical function in early embryogenesis, nuclear transport efficiency, and maintaining proper gene expression regulation during cellular growth and differentiation.
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