Integrin Alpha D / CD11D (ITGAD) Antibody
260€ (100 µl)
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name
Integrin Alpha D / CD11D (ITGAD) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx101638
tested applications
WB, IHC
Description
Polyclonal Antibody to Integrin Alpha D (ITGaD).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Integrin Alpha D / CD11D (ITGAD) Immunogen: abx067277 - Recombinant Human ITGAD (Phe879-Asn1099) expressed in E. coli |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13349 |
| Gene ID | 3681 |
| Alias | ADB2,CD11D,Integrin alpha-D,CD11 antigen-like family member D,Leukointegrin alpha D |
| Background | Antibody anti-ITGAD |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ITGAD (integrin subunit alpha D), also known as CD11d, is a member of the integrin family of cell adhesion molecules. Integrins are heterodimeric receptors consisting of an alpha and a beta subunit, which mediate cell-cell and cell-extracellular matrix interactions. ITGAD pairs with the beta-2 integrin subunit (CD18) to form the αDβ2 (CD11d/CD18) integrin. This integrin is predominantly expressed on myeloid cells, including macrophages, dendritic cells, monocytes, and natural killer (NK) cells, as well as certain subpopulations of lymphocytes. ITGAD, as part of the β2 integrin subfamily, plays a critical role in immune responses, particularly in cell adhesion, migration, and phagocytosis. ITGAD is the least well-characterized among the beta-2 integrins, but emerging research has highlighted its significance in specialized immune responses, such as the clearance of apoptotic cells, regulation of inflammation, and leukocyte recruitment to chronic inflammatory sites. Additionally, ITGAD has been implicated in processes such as tissue remodeling and wound healing. Due to its involvement in these crucial immune processes, ITGAD has garnered increasing attention in the study of immune system regulation and pathologies, including chronic inflammation, autoimmune diseases, and cancer.
Related Products
Human Integrin Alpha D / CD11D (ITGAD) Protein
Human Integrin Alpha D (ITGaD) is a recombinant Human protein expressed in E. coli.
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