Interleukin 1 Receptor Antagonist (IL1RN) Antibody
260€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Interleukin 1 Receptor Antagonist (IL1RN) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx339231
Tested Applications
ELISA, IHC
Description
IL1RN Antibody is a Rabbit Polyclonal against IL1RN.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 1 Receptor Antagonist (IL1RN) Immunogen: Fusion protein of human IL1RN. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P18510 |
| Gene ID | 3557 |
| OMIM | 147679 |
| Alias | IL-1ra,IL1RA,IL-1RA,IL-1F3,ICIL-1RA,IL1 inhibitor |
| Background | Antibody anti-IL1RN |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
IL1RN is a natural anti-inflammatory protein that inhibits the activity of interleukin-1α (IL1α) and interleukin-1β (IL1β) by competitively binding to the IL-1 receptor (IL1R) without triggering downstream signaling This inhibition prevents IL1-mediated activation of NF-κB and subsequent production of pro-inflammatory cytokines IL1RN plays a crucial role in balancing inflammation, protecting tissues from excessive immune responses, and maintaining homeostasis Deficiency or mutations in IL1RN lead to autoinflammatory diseases, such as deficiency of IL1RN (DIRA), characterized by systemic inflammation and tissue damage IL1RN-based therapies, like anakinra, are used for treating rheumatoid arthritis, gout, and cryopyrin-associated periodic syndromes (CAPS), where IL1 overproduction drives disease progression
Productos relacionados
Interleukin 1 Receptor Antagonist (IL1RN) Antibody
IL1RN Antibody is a Rabbit Polyclonal antibody against IL1RN. The protein encoded by this gene is a member of the interl…
Ver producto
Interleukin 1 Receptor Antagonist (IL1RN) Antibody
The protein is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alp…
Ver producto
Human Interleukin 1 Receptor Antagonist (IL1RN) ELISA Kit
Human Interleukin 1 Receptor Antagonist (IL1RN) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of H…
Ver producto