Interleukin 12 Subunit Beta (IL12B) Antibody
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Description
Interleukin 12 Subunit Beta (IL12B) Antibody is a recombinant Mouse Monoclonal against IL12B.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 12 Subunit Beta (IL12B) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB (Predicted): 0.2-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml, FCM: 10 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b Kappa |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29460 |
| Gene ID | 3593 |
| Background | Antibody anti-IL12B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
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IL12B antibody
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
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