Krueppel-Like Factor 10 (KLF10) Antibody

312€ (60 µl)
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935106861
info@markelab.com
name
Krueppel-Like Factor 10 (KLF10) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx004909
tested applications
WB
Description
KLF10 Antibody is a Rabbit Polyclonal antibody against KLF10. This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Krueppel-Like Factor 10 (KLF10) |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13118 |
| Gene ID | 7071 |
| NCBI Accession | NP_001027453.1, NM_001032282.3, NP_005646.1, NM_005655.3 |
| OMIM | 601878 |
| Background | Antibody anti-KLF10 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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KLF10 antibody
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis(By similarity). May play a role in the cell cycle regulation.
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