Lectin-Galactoside Binding Soluble 3 (LGALS3) Antibody
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Description
LGALS3 Antibody is a Rabbit Polyclonal antibody against LGALS3. Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apop-tosis. The galectin-3 protein, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, contains a single carbohydrate binding domain, which binds galactose-containing glycoconjugates. Galectin-3 is expressed in colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. Upregulated expression of galectin-3 is involved in cancer progression and metastasis. Galectin-3 mediates the endocytosis of ∫1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn’s disease. It may also be used as a marker for diagnosing cases involving Hurthle cell adenomas and carcinomas.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Lectin-Galactoside Binding Soluble 3 (LGALS3) |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P17931 |
| Gene ID | 3958 |
| NCBI Accession | NP_002297.2 |
| Background | Antibody anti-LGALS3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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LGALS3 antibody
Galectins are a family of animal lectins defined by shared characteristic amino-acid sequences and affinity for β-galactose-containing oligosac-charides(PMID: 8063692). Galectin-3 contains one carbohydrate recognition domain(CRD) and a proline-and glycine-rich N-terminal domain through which is able to form oligomers. Galectin-3 is widely expressed in many normal tissues and a variety of tumors.
Ver ProductoLGALS3 antibody
Galectins are a family of animal lectins defined by shared characteristic amino-acid sequences and affinity for β-galactose-containing oligosac-charides(PMID: 8063692). Galectin-3 contains one carbohydrate recognition domain(CRD) and a proline-and glycine-rich N-terminal domain through which is able to form oligomers. Galectin-3 is widely expressed in many normal tissues and a variety of tumors.
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