Macrophage Stimulating 1 Receptor (MST1R) Antibody
273€ (100 µl)
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935106861
info@markelab.com
name
Macrophage Stimulating 1 Receptor (MST1R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx103634
tested applications
IHC
Description
Polyclonal Antibody to Macrophage Stimulating 1 Receptor (MST1R).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Macrophage Stimulating 1 Receptor (MST1R) Immunogen: MST1R (Ile89-Ser275) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Macrophage-stimulating protein receptor,RON,SEA,PTK8,CD136,NPCA3,CDw136,MSP receptor,Protein-tyrosine kinase 8 |
| Background | Antibody anti-MST1R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
MST1R, also known as RON receptor tyrosine kinase or Macrophage-Stimulating 1 Receptor, is a member of the MET proto-oncogene family. This receptor belongs to the receptor tyrosine kinase (RTK) family and plays a crucial role in various physiological processes, particularly those involving inflammation, tissue repair, cell survival, and migration. MST1R is primarily expressed in macrophages, epithelial cells, and some immune cell types and mediates its effects through interaction with its ligand, Macrophage-Stimulating Protein (MSP). Ligand binding to MST1R activates intracellular signaling cascades, leading to cell proliferation, survival, and migration, thus influencing immune responses, tissue repair, and inflammatory responses. Research has identified the significance of MST1R in the pathology of various diseases, including cancer and fibrotic disorders, due to its ability to promote cellular processes often dysregulated in malignancy and tissue scarring. In cancer, for example, MST1R is often overexpressed or mutated, leading to enhanced tumor progression, metastasis, and treatment resistance. Consequently, MST1R has emerged as a target of interest in the development of anti-cancer therapeutics.
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