Mouse A-kinase anchor protein 8 (AKAP8) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse A-kinase anchor protein 8 (AKAP8) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501418
tested applications
ELISA
Description
Mouse A-kinase anchor protein 8 (AKAP8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse A-kinase anchor protein 8 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | A-kinase anchor protein 8 (AKAP8) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9DBR0 |
| Gene ID | 56399 |
| Alias | AKAP8, AKAP95 |
| Background | Elisa Kits for: AKAP8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
AKAP8, also known as AKAP95, is a nuclear scaffold protein that anchors PKA and other enzymes to chromatin and nuclear compartments, playing key roles in RNA processing, mitotic progression, and chromatin remodeling. AKAP8 regulates PKA-dependent phosphorylation of nuclear substrates involved in RNA splicing and transcriptional regulation, ensuring efficient gene expression during cell cycle progression. It also participates in mitotic events by anchoring protein phosphatase 1 (PP1) and chromatin-associated proteins to organize chromosome condensation and segregation. AKAP8 interacts with histones and chromatin remodelers, linking it to epigenetic regulation during cell differentiation and stress responses. Dysregulation of AKAP8 has been associated with aberrant gene expression, chromosomal instability, and cancer progression. In addition, AKAP8 plays a role in viral replication, where it acts as a scaffold for proteins involved in nuclear viral RNA export. Its localization and function make it a crucial regulator of nuclear processes.
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