Mouse Atypical chemokine receptor 2 (ACKR2) ELISA Kit
715€ (96 tests)
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935106861
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name
Mouse Atypical chemokine receptor 2 (ACKR2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx500745
tested applications
ELISA
Description
Mouse Atypical chemokine receptor 2 (ACKR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Atypical chemokine receptor 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Atypical chemokine receptor 2 (ACKR2) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O08707 |
| Gene ID | 59289 |
| Alias | CCBP2,CCR10,CCR9,CMKBR9,D6 |
| Background | Elisa Kits for: ACKR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
ACKR2 is a non-classical chemokine receptor that functions as a decoy and scavenger receptor, specifically binding pro-inflammatory CC chemokines to modulate immune responses and resolve inflammation. Unlike signaling chemokine receptors, ACKR2 does not trigger intracellular signaling but instead internalizes and degrades its ligands, reducing chemokine availability and dampening inflammation. It is primarily expressed on lymphatic endothelial cells and plays a critical role in maintaining immune homeostasis by clearing chemokines from tissues and promoting the resolution of inflammation. ACKR2 is also involved in shaping chemokine gradients, ensuring proper immune cell trafficking and preventing chronic inflammatory conditions. Dysregulation of ACKR2 has been linked to autoimmune diseases, chronic inflammation, and cancer, where its altered expression may contribute to pathological immune cell infiltration and tumor progression. Its scavenging activity and role in regulating immune responses make ACKR2 a potential therapeutic target for inflammatory and immune-related diseases.
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