Mouse CD177 Antigen / NB1 (CD177) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Mouse CD177 Antigen / NB1 (CD177) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx517603
tested applications
ELISA
Description
Mouse CD177 Antigen / NB1 (CD177) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse CD177 Antigen / NB1 (CD177) concentrations.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | CD177 Antigen / NB1 (CD177) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8R2S8 |
| Alias | NB1,PRV1,HNA2A,PRV-1,HNA-2a,NB1 GP,Human neutrophil alloantigen 2a,NB1 glycoprotein,Polycythemia rubra vera protein 1 |
| Background | Elisa Kits for: CD177 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
CD177, also known as neutrophil antigen B1 (NB1) or PRV1 (Polycythemia Rubra Vera 1), is a glycoprotein primarily expressed on the surface of neutrophils. It is encoded by the CD177 gene on chromosome 19q13.31 and plays a significant role in immune function and inflammation. CD177 is best known for its association with polycythemia vera, a myeloproliferative disorder, and its involvement in other immune-related conditions such as neutrophil-specific antigens and immune-mediated thrombocytopenia. The CD177 protein is expressed variably on neutrophils, with only a subset of the neutrophil population expressing CD177 in individuals. This variability has clinical relevance, as CD177-positive neutrophils display distinct functional characteristics compared to CD177-negative neutrophils. One of the primary functions of CD177 is to bind to platelet endothelial cell adhesion molecule 1 (PECAM-1/CD31), facilitating neutrophil transmigration across endothelial barriers during inflammatory responses. CD177 has gained attention for its role in various inflammatory and autoimmune diseases, as well as in complications related to transfusion medicine and pregnancy. Moreover, mutations and polymorphisms in CD177 are associated with a variety of neutrophil-related disorders, including polycythemia vera and alloimmune neonatal neutropenia.
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