Mouse Cytoplasmic protein NCK2 (NCK2) ELISA Kit
715€ (96 tests)
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935106861
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name
Mouse Cytoplasmic protein NCK2 (NCK2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx534662
tested applications
ELISA
Description
Mouse Cytoplasmic protein NCK2 (NCK2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Cytoplasmic protein NCK2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Cytoplasmic protein NCK2 (NCK2) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O55033 |
| Gene ID | 17974 |
| Alias | NCK2, GRB4, NCKbeta, NCK adaptor protein 2 |
| Background | Elisa Kits for: NCK2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
NCK2, also called Grb4, is a close homolog of NCK1 and functions as an adaptor protein linking receptor tyrosine kinases (RTKs) and cytoplasmic signaling molecules. It contains three SH3 domains and one SH2 domain, enabling it to interact with proteins involved in actin cytoskeletal regulation, cell adhesion, and migration. NCK2 mediates signaling pathways that regulate cell growth, differentiation, and survival, particularly through interactions with proteins like WASP, WAVE, and PAK kinases. It has specialized roles in embryonic development, angiogenesis, and neuronal growth. Dysregulation of NCK2 is implicated in cancer, where it promotes migration and invasion through actin remodeling. Knockout models show impaired embryonic development, angiogenesis defects, and abnormalities in cell motility, underscoring its critical role in cytoskeletal dynamics and signal transduction.
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