Mouse DNA-Binding Protein Ikaros (IKZF1) Protein
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Description
Mouse DNA-Binding Protein Ikaros (IKZF1) Protein is a recombinant protein expressed in E. coli.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | DNA-binding protein Ikaros (IKZF1) |
| Host | E. coli |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Sequence Fragment: Full length, 1-517 AA. Tag: The tag will be determined during the manufacturing process. Please contact us if you have any tag requirements. Validity: 6 months in liquid form, or 12 months in lyophilized form. |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Size 3 | 1 mg |
| Tested Applications | SDS-PAGE |
| Buffer | To be determined. Please contact us with any special requirements. |
| Availability | Shipped within 2-3 months. |
| Storage | Store at -20 °C for up to 6 months in liquid form, or for up to 12 months in lyophilized form. Aliquots can be stored at 4 °C for up to one week. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q03267 |
| Background | Protein IKZF1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
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IKZF1 antibody
Transcription regulator of hematopoietic cell differentiation(PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B-and T-cells. Binds and activates the enhancer(delta-A element) of the CD3-delta gene. Repressor of the TDT(fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF(SWI/SNF), in a single complex(PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells(RPCs)(By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms(PubMed:17135265, PubMed:17934067).
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