Mouse Docking protein 2 (Dok2) ELISA Kit

Este producto es parte de DOK - Docking protein
Mouse Docking protein 2 (Dok2) ELISA Kit
715€ (96 tests)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

Name
Mouse Docking protein 2 (Dok2) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx556046
Tested Applications
ELISA

Description

Mouse Docking protein 2 (Dok2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse DOK2 concentrations in serum, plasma and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Docking protein 2 (Dok2)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
0.078 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Serum, plasma and other biological fluids.
Availability
Shipped within 1-3 weeks.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
O70469
Alias
Downstream of tyrosine kinase 2,p56DOK,p56dok-2
Background
Elisa Kits for: DOK2
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

Docking protein 2 (DOK2) is another member of the DOK family, predominantly expressed in hematopoietic cells. Like DOK1, DOK2 functions as a negative regulator of tyrosine kinase-mediated signaling pathways. It is essential for modulating immune cell activation, particularly in T cells, B cells, and macrophages. DOK2 interacts with various signaling proteins, such as SH2-containing phosphatase 2 (SHP2) and Ras-GAP, to dampen downstream signaling cascades. This regulation is vital for maintaining immune homeostasis and preventing overactivation that could lead to autoimmunity. DOK2 has also been identified as a tumor suppressor, with its inactivation or downregulation contributing to the pathogenesis of leukemias and other cancers. Its roles in both immune regulation and oncogenesis make it a key target for therapeutic research.

Productos relacionados

abx000302

DOK2 (pY299) Antibody

DOK2 (pY299) Antibody is a Rabbit Polyclonal antibody against DOK2 (pY299). The protein encoded by this gene is constitu…

Ver producto
abx005843

Docking Protein 2 (DOK2) Antibody

DOK2 Antibody is a Rabbit Polyclonal Antibody against DOK2.…

Ver producto
abx112148

Docking Protein 2 (DOK2) Antibody

Docking Protein 2, 56 kDa Antibody is a Rabbit Polyclonal antibody against Docking Protein 2, 56 kDa.…

Ver producto