Mouse Glycophorin A (GYPA) Protein
234€ (10 µg)
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935106861
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name
Mouse Glycophorin A (GYPA) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx066878
tested applications
WB, SDS-PAGE
Description
Mouse Glycophorin A (GYPA) is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Glycophorin A (GYPA) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Val108 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 15.0 kDa Observed MW (SDS-PAGE): 19/20 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P14220 |
| Alias | MNS blood group,MN,GPA,MNS,GPSAT,PAS-2,CD235a,MN sialoglycoprotein,Sialoglycoprotein alpha |
| Background | Protein GYPA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Glycophorin A (GYPA) is a major sialoglycoprotein found on the membrane of human red blood cells (RBCs) and plays a crucial role in the structure and function of the erythrocyte membrane. As a prominent surface protein, it is highly glycosylated and carries sialic acid residues, which contribute to the overall negative charge on the RBC surface, helping to prevent cell aggregation and maintain blood flow. GYPA is most recognized for its involvement in the MNS blood group system, which includes the MN and Ss antigens; variations in the GYPA gene form the molecular basis for these antigenic determinants. This protein is highly relevant in transfusion medicine due to its immunogenic potential and role in blood group antigenicity. In addition to its structural role, GYPA interacts with various pathogens, particularly Plasmodium falciparum, the causative agent of malaria. This interaction is significant for the pathogen’s adhesion to RBCs during infection. GYPA also functions as a receptor for viruses like influenza, playing a broader role in infectious disease dynamics.
