Mouse High Mobility Group Protein B1 (HMGB1) Protein
221€ (10 µg)
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935106861
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name
Mouse High Mobility Group Protein B1 (HMGB1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067106
tested applications
WB, SDS-PAGE
Description
Mouse HMGB1 is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | High Mobility Group Protein B1 (HMGB1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Glu215 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 26.2 kDa Observed MW: 33 kDa (determined by SDS-PAGE) Possible reasons why the actual band size differs from the predicted band size: 1. Splice variants. Alternative splicing may create different sized proteins from the same gene. 2. Relative charge. The composition of amino acids may affect the charge of the protein. 3. Post-translational modification. Phosphorylation, glycoslyation, methylation etc. may affect the band size. 4. Post-translational cleavage. Many proteins are synthesised as pro-proteins, and then cleaved to give the active form. 5. Polymerisation of the target protein. Dimerisation, multimerisation etc. will increase the band size observed. |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P63158 |
| Gene ID | mmu:15289 |
| Alias | HMG1,HMG3,HMG-1,SBP-1,Amphoterin |
| Background | Protein HMGB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in ddH2O to a concentration between 0.1-0.25 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 50 µg/ml |
Descripción
HMGB1 is a non-histone nuclear protein involved in DNA repair, replication, and transcriptional regulation, but it also functions as a damage-associated molecular pattern (DAMP) protein when released extracellularly Upon cellular stress or necrosis, HMGB1 is actively secreted or passively released, triggering immune responses by interacting with receptors such as RAGE and TLR4 HMGB1 is critical in mediating inflammation, immune activation, and tissue injury, playing roles in diseases like sepsis, autoimmune disorders, and cancer It promotes cell migration, angiogenesis, and tumor progression, while dysregulated HMGB1 signaling is linked to chronic inflammation and metastasis Targeting HMGB1 holds therapeutic promise for modulating immune responses in inflammatory diseases, neurodegeneration, and cancer
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