Mouse Interleukin 18 Receptor 1 (IL18R1) Protein
247€ (10 µg)
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Name
Mouse Interleukin 18 Receptor 1 (IL18R1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx067488
Tested Applications
WB, SDS-PAGE
Description
Mouse Interleukin 18 Receptor 1 (IL18R1) is a recombinant Mouse protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 18 Receptor 1 (IL18R1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Thr391-Ala518 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 16.2 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q61098 |
| Alias | L18R1, CD218a, CDw218a,IL-18Ralpha,IL-18 R alpha,IL-1 R5,IL-18RA,IL18RA,IL1RRP |
| Background | Protein IL18R1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
IL18R1 is a key receptor in the interleukin-18 (IL-18) signaling pathway, mediating pro-inflammatory immune responses and host defense mechanisms. It forms a heterodimeric complex with IL18RAP (Interleukin 18 Receptor Accessory Protein) upon IL-18 ligand binding, leading to the recruitment of the MyD88 adaptor protein and activation of downstream NF-κB, MAPK, and JNK pathways. IL18R1 is highly expressed on immune cells, including T cells, natural killer (NK) cells, and macrophages, where it plays critical roles in cytokine production, immune cell activation, and Th1 immune responses. It contributes to the regulation of inflammation, pathogen defense, and tissue repair in response to infections, stress, and inflammatory stimuli. Dysregulation of IL18R1 is linked to autoimmune diseases, chronic inflammation, and cancers, where excessive IL-18 signaling promotes tissue damage and tumor progression. Knockout studies reveal impaired cytokine production, reduced NK cell activation, and weakened pathogen clearance, underscoring its critical role in innate and adaptive immunity, inflammatory signaling, and immune surveillance.
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