Mouse Islet Amyloid Polypeptide (IAPP) Peptide (BSA)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Islet Amyloid Polypeptide Protein (BSA) is a Mouse protein conjugated to BSA.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Islet Amyloid Polypeptide (IAPP) |
| Host | Synthetic |
| Assay Type | Activity: Not tested |
| Origin | Mouse |
| Conjugation | BSA |
| Expression | Synthetic |
| Purity | > 90% |
| Size 1 | 100 µg |
| Size 2 | 200 µg |
| Size 3 | 500 µg |
| Size 4 | 1 mg |
| Size 5 | 5 mg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | Amylin,IAP,Diabetes-Associated Peptide Diabetes-Associated Peptide |
| Background | Protein IAPP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Islet amyloid polypeptide (IAPP), also known as amylin, is a 37-residue peptide hormone produced by the pancreatic beta cells. IAPP plays a role in regulating glucose metabolism, primarily by slowing gastric emptying and reducing glucagon secretion. in conditions such as type 2 diabetes mellitus, IAPP can misfold and aggregate, forming amyloid fibrils. These amyloid fibrils can accumulate in the pancreas, particularly in the islets of Langerhans. This aggregation of amyloid fibrils is associated with beta cell dysfunction, apoptosis , and progression of type 2 diabetes. Amyloid deposits originating from islet amyloid polypeptide (IAPP), are frequently observed in the pancreatic islets of individuals with type 2 diabetes mellitus or those afflicted with insulinoma cancer. Although the connection between amylin and the onset of type 2 diabetes has been recognized for some time, pinpointing its direct causative role has proved challenging. Some research indicates that amylin, and beta-amyloid (Abeta) linked to Alzheimer's disease, could trigger apoptotic cell death in insulin-producing beta cells. This effect may have implications for the progression of type 2 diabetes.
Related Products
Human Islet Amyloid Polypeptide (IAPP) CLIA Kit
Human Islet Amyloid Polypeptide (IAPP) Chemiluminescent Immunoassay (CLIA) Kit is a Competitive Chemiluminescent Immunoassay (CLIA) Kit for use with serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Ver ProductoRabbit Islet Amyloid Polypeptide (IAPP) ELISA Kit
Rabbit Islet Amyloid Polypeptide (IAPP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rabbit IAPP concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Ver ProductoDog Islet Amyloid Polypeptide (IAPP) ELISA Kit
Dog Islet Amyloid Polypeptide (IAPP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Dog Islet Amyloid Polypeptide (IAPP) concentrations in serum, plasma and other biological fluids.
Ver Producto