Mouse Kin of IRRE-Like Protein 1 (KIRREL1) Protein (Active)

Este producto es parte de KIRREL - kirre like nephrin family adhesion molecule
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1118€ (100 µg)

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935106861
info@markelab.com
name
Mouse Kin of IRRE-Like Protein 1 (KIRREL1) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692128
tested applications
SDS-PAGE

Description

Kin Of Irre-Like Protein 1 (KIRREL1) protein is a recombinant Mouse protein expressed in HEK293 cells.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Kin Of Irre-Like Protein 1 (KIRREL1)
Host
HEK293 cells
Assay Type
Activity: Active
Sequence Fragment: Met1-Leu525
Tag: C-terminal His tag
Origin
Mouse
Observed MW
53.8 kDa
Expression
Recombinant
Purity
> 98% (SDS-PAGE)
Size 1
100 µg
Form
Lyophilized
Tested Applications
SDS-PAGE
Buffer
Prior to lyophilization: Sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.
Dry Ice
No
UniProt ID
Q80W68
NCBI Accession
NP_570937.2
Alias
NEPH1,KIRREL,NPHS23,Nephrin-like protein 1,Kin of irregular chiasm-like protein 1,Kin of IRRE-like protein 1
Background
Protein KIRREL1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Endotoxin Level: < 1.0 EU per µg (LAL method).

Descripción

KIRREL1, also known as nephrin-like protein 1, is a transmembrane protein primarily expressed in the glomerular podocytes of the kidney, where it plays a crucial role in filtration barrier integrity. It belongs to the immunoglobulin superfamily, featuring Ig-like domains that mediate cell-cell adhesion and interactions with other proteins in the slit diaphragm, a key structure in glomerular filtration. KIRREL1 is critical for maintaining podocyte structure and function. Mutations in KIRREL1 are associated with nephrotic syndrome, a condition characterized by proteinuria and kidney dysfunction. Its role in stabilizing the filtration barrier makes it essential for renal physiology.
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