Mouse Linker For Activation Of T-Cells Family, Member 2 (LAT2) Protein
234€ (10 µg)
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Name
Mouse Linker For Activation Of T-Cells Family, Member 2 (LAT2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx168382
Tested Applications
WB, SDS-PAGE
Description
Mouse Linker For Activation Of T-Cells Family, Member 2 Protein is a recombinant Mouse protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Linker For Activation Of T-Cells Family, Member 2 (LAT2) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Cys29-Val193 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 22.6 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9JHL0 |
| Alias | LAT2,LAB, NTAL, WBSCR15, WBSCR5, WSCR5, HSPC046 |
| Background | Protein LAT2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Linker for activation of T-cells family member 2 (LAT2), also known as NTAL (Non-T cell Activation Linker), is an adaptor protein expressed in various immune cells, including B cells, mast cells, and NK cells. LAT2 functions analogously to LAT by facilitating signal transduction from immunoreceptors, such as the B-cell receptor (BCR) and Fc receptors, to downstream signaling cascades. Upon receptor engagement, LAT2 undergoes tyrosine phosphorylation, enabling it to recruit signaling molecules, such as Grb2 and PLCγ, which are essential for calcium mobilization and activation of the MAPK pathway. LAT2 plays a crucial role in immune responses, particularly in B-cell activation, mast cell degranulation, and cytokine production. Unlike LAT, LAT2 exhibits a broader expression pattern and participates in both adaptive and innate immunity. Its dysregulation has been implicated in allergic reactions and immune cell hyperactivity, making it a potential therapeutic target in allergic and inflammatory diseases.
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