Mouse Protein Tyrosine Kinase 2 Beta (PTK2b) Protein
234€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Mouse Protein Tyrosine Kinase 2 Beta (PTK2b) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168696
tested applications
WB, SDS-PAGE
Description
Mouse PTK2b Protein is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Protein Tyrosine Kinase 2 Beta (PTK2b) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ile704-Gly941 Tag: N-terminal His tag and GST tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 57.2 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9QVP9 |
| Alias | PKB,PTK,CAKB,FAK2,PYK2,CADTK,FADK2,RAFTK,Proline-rich tyrosine kinase 2,Related adhesion focal tyrosine kinase,Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta,CAK-beta,Calcium-dependent tyrosine kinase |
| Background | Protein PTK2B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Protein Tyrosine Kinase 2 Beta (PTK2B), also known as Pyk2, is a cytoplasmic tyrosine kinase related to PTK2 but has distinct roles in calcium signaling, immune responses, and neuronal function. PTK2B is activated by increased intracellular calcium levels, G-protein-coupled receptors (GPCRs), and environmental stress. Structurally, PTK2B shares a similar architecture with PTK2, including an FERM domain, kinase domain, and focal adhesion targeting region, but has a unique sensitivity to calcium signaling. PTK2B regulates cytoskeletal dynamics, cell adhesion, and migration, particularly in immune cells and neurons. PTK2B is highly expressed in the nervous system and plays a pivotal role in synaptic plasticity, neuronal migration, and memory formation. Its overactivation has been linked to neurodegenerative diseases such as Alzheimer’s disease by modulating tau phosphorylation and beta-amyloid signaling. In the immune system, PTK2B influences macrophage activation, B-cell responses, and inflammatory signaling pathways. Dysregulation of PTK2B is also associated with certain cancers, where it promotes cell survival, invasion, and tumor progression. Targeting PTK2B is being explored for potential therapeutic interventions in cancer and neuroinflammation.
