Mouse Activin Receptor Type-1-Like (ACVRL1) Protein
234€ (10 µg)
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935106861
info@markelab.com
name
Mouse Activin Receptor Type-1-Like (ACVRL1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691227
tested applications
SDS-PAGE
Description
Activin Receptor Type-1-Like (ACVRL1) protein is a recombinant Mouse protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Activin Receptor Type-1-Like (ACVRL1) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Asp23-Pro119 Tag: C-terminal Fc tag |
| Origin | Mouse |
| Observed MW | Calculated MW: 38.1 kDa Observed MW (SDS-PAGE): 55-60 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | 0.2 µm filtered prior to lyophilization. |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5%-8% Trehalose, Mannitol and 0.01% Tween 80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q61288 |
| Gene ID | 11482 |
| Alias | Activin receptor-like kinase 1,ALK-1,SKR3 |
| Background | Protein ACVRL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile H2O to prepare a stock solution of concentration 0.25 mg/ml. Do not vortex. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
ACVRL1, also known as ALK1, is a type I receptor that primarily binds BMP9 and BMP10. It is critical for vascular development and endothelial cell function. ACVRL1 regulates angiogenesis through the SMAD1/5/8 signaling pathway, promoting endothelial proliferation and vessel stability. Mutations in ACVRL1 cause hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation and recurrent bleeding. It is primarily expressed in vascular endothelial cells.
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