Mouse Signal Regulatory Protein Beta 1 (SIRPb1) Protein
234€ (10 µg)
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935106861
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name
Mouse Signal Regulatory Protein Beta 1 (SIRPb1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx165987
tested applications
WB, SDS-PAGE
Description
Mouse Signal Regulatory Protein Beta 1 is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Signal Regulatory Protein Beta 1 (SIRPb1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Asp129-Thr342 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 27.8 kDa Observed MW (SDS-PAGE): 30 kDa |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | CD172 antigen-like family member B,CD172b,SIRP-BETA-1 |
| Background | Protein SIRPB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in ddH2O to a concentration between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Signal regulatory protein beta-1 (SIRPB1) is a transmembrane glycoprotein that is part of the signal regulatory protein (SIRP) family within the immunoglobulin superfamily (IgSF). SIRPB1 is primarily expressed on myeloid cells, such as macrophages, dendritic cells, and granulocytes, and functions as an activating receptor involved in immune regulation, phagocytosis, and cellular signaling. Unlike SIRPA, another family member which interacts with CD47 to deliver inhibitory signals to prevent “self” cell phagocytosis, SIRPB1 typically serves as an activating receptor and does not interact directly with CD47. SIRPB1 plays a role in modulating immune responses, particularly through its association with DAP12 (DNAX activation protein of 12 kDa), an adaptor molecule containing immunoreceptor tyrosine-based activation motifs (ITAMs). Upon activation, SIRPB1 influences signaling cascades that lead to pro-inflammatory cytokine release, phagocytosis, and cellular migration, especially in response to pathogens or tissue injury. Because of its involvement in immune activation, SIRPB1 has become of interest in cancer, infectious diseases, and inflammatory disorders.
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