Mouse Transcription Factor E2F5 (E2F5) ELISA Kit

Este producto es parte de E2F - E2F Transcription Factor
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715€ (96 tests)

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935106861
info@markelab.com
name
Mouse Transcription Factor E2F5 (E2F5) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx520212
tested applications
ELISA

Description

Mouse Transcription Factor E2F5 (E2F5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Transcription Factor E2F5 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Transcription Factor E2F5 (E2F5)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q61502
Gene ID
13559
Alias
E2F-5
Background
Elisa Kits for: E2F5
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Descripción

E2F5 is a transcriptional repressor that functions similarly to E2F4 in controlling cell cycle exit, quiescence, and differentiation. It forms complexes with pocket proteins such as p130 and p107 to repress proliferation-related genes, particularly during G0 and early G1 phases. E2F5 is highly expressed in non-proliferative and terminally differentiated cells, where it ensures proper tissue development and homeostasis. E2F5 plays a critical role in embryonic development, especially in the formation of the central nervous system, lungs, and cardiac tissues. Mutations in E2F5 have been linked to ciliopathies such as hydrocephalus, where impaired regulation of cilia-related genes disrupts fluid flow and tissue organization. Knockout studies reveal developmental defects, including hydrocephalus and improper cell cycle control, demonstrating E2F5’s importance in maintaining cellular quiescence, differentiation, and developmental stability.

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